--- title: "AACR22: A COVID 19 vaccine for people with B-cell deficiency" description: Although an array of scientific advancements is leashing the COVID 19 pandemic to some extent, still a large number of people w/ compromised immune systems image: https://blog.acutis.com/hubfs/Imported_Blog_Media/6f340a_bc9908689ede4694b2f61cea55e858b6~mv2-2.jpeg --- [Skip to content](https://blog.acutis.com/post/aacr22-a-covid-19-vaccine-for-people-with-b-cell-deficiency#main-content) Close - About - [What is Acutis?](https://acutis-21140295.hs-sites.com/what-is-acutis) - [Our Team](https://acutis-21140295.hs-sites.com/we-are-acutis) - [Guiding Principles](https://acutis-21140295.hs-sites.com/guiding-principles) - [Compliance](https://acutis-21140295.hs-sites.com/en/compliance) - [Accreditations](https://acutis-21140295.hs-sites.com/accreditations) - [Careers](https://acutis-21140295.hs-sites.com/careers) - [Continuing Education](https://acutis-21140295.hs-sites.com/webinars-symposium) - Providers - 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[Insights](https://blog.acutis.com) - [Contact](https://acutis-21140295.hs-sites.com/contact) PHONE HOTLINE: [844-522-8847](tel:+1844-522-8847)E-MAIL: [service@acutis.com](mailto:service@acutis.com) [i-Acutis](https://acutis.careevolve.com/doctors/framepage.asp) ![COVID 19 PCR testing ](https://blog.acutis.com/hs-fs/hubfs/Imported_Blog_Media/6f340a_bc9908689ede4694b2f61cea55e858b6~mv2-2.jpeg?width=300&name=6f340a_bc9908689ede4694b2f61cea55e858b6~mv2-2.jpeg) [Acutis](https://blog.acutis.com/author/acutis)Jun 6, 2022 12:00:00 AM1 min read # AACR22: A COVID 19 vaccine for people with B-cell deficiency [Previous](https://blog.acutis.com/post/acutis-names-abdel-halim-pharmd-msc-phd-dabcc-faacc-as-chief-scientific-officer) [Next](https://blog.acutis.com/post/the-overlooked-pandemic-of-antimicrobial-resistance) ![](https://blog.acutis.com/hubfs/Imported_Blog_Media/6f340a_bc9908689ede4694b2f61cea55e858b6~mv2-3.jpeg) Although an array of scientific advancements is leashing the COVID-19 pandemic to some extent, still a large number of people with compromised immune systems – have been left behind. Because of the recent advancements in cancer therapies, including several chemotherapies and immunotherapies, survival among cancer patients has significantly improved. Unfortunately, these patients remain immunocompromised for a prolonged time as these therapies destroy B-cells that are responsible for antibody-mediated protection, thus lacking sufficient humoral immune responses after vaccination with current SARS-CoV-2 vaccines. The human [immune system](https://info.acutis.com/providers) comprises two lines of defense – B-Cell mediated antibody response and T- Cell-mediated innate response. When patients are immunocompromised, their B-cells are affected, but their T-Cells and innate immune system remain intact. A team of scientists has created a vaccine containing six SARS-CoV-2 antigens from different parts of the virus, unlike just the spike proteins in current vaccines, making it capable of inducing more robust and broader T-cell immunity than the current vaccines. Supported with very robust preliminary data from Phase I/II clinical trials showing T-cell immunity in 71% of subjects after 14 days that increased to 93% in 28 days, a great sigh of relief is on the near horizon for this vulnerable and isolated population. [**Read the full article here.**](https://www.biotechniques.com/cancer-research/a-covid-19-vaccine-for-people-with-b-cell-deficiency/) ![avatar](https://blog.acutis.com/hs-fs/hubfs/Sales%20materials%202023/Brand/logo-acutis%20HD-2022-1.png?width=290&name=logo-acutis%20HD-2022-1.png) #### [Acutis](https://blog.acutis.com/author/acutis) Our team of scientific experts is here to help you understand the trends in infectious disease, clinical toxicology, and Biosciences that are happening in the world. [mailto:service@acutis.com](mailto:service@acutis.com) ## RELATED ARTICLES [![Acutis-white](https://info.acutis.com/hs-fs/hubfs/Acutis-white.png?width=100&name=Acutis-white.png)](https://www.acutis.com/) **Insights. Answers. 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Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.© 2026 Acutis Diagnostics ```json { "@context" : "https://schema.org", "@type" : "Organization", "address" : { "@type" : "PostalAddress", "addressCountry" : "", "addressLocality" : "Hicksville", "addressRegion" : "NY", "postalCode" : "11801", "streetAddress" : "400 Karin Lane" }, "email" : "service@acutis.com", "knowsLanguage" : "en", "logo" : { "@type" : "ImageObject", "url" : "https://f.hubspotusercontent40.net/hubfs/21140295/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc.", "telephone" : "844-522-8847", "url" : "https://blog.acutis.com/post/aacr22-a-covid-19-vaccine-for-people-with-b-cell-deficiency" } ``` ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "abstract" : "Although an array of scientific advancements is leashing the COVID 19 pandemic to some extent, still a large number of people w/ compromised immune systems", "author" : { "@type" : "Person", "name" : "Acutis" }, "dateModified" : "April 6, 2023 1 AM", "datePublished" : "June 6, 2022 4 AM", "headline" : "AACR22: A COVID 19 vaccine for people with B-cell deficiency", "image" : "https://info.acutis.com/hubfs/Imported_Blog_Media/6f340a_bc9908689ede4694b2f61cea55e858b6~mv2-2.jpeg", "inLanguage" : "en", "keywords" : "[NEWS]", "mainEntityOfPage" : { "@type" : "WebPage" }, "name" : "AACR22: A COVID 19 vaccine for people with B-cell deficiency", "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://f.hubspotusercontent40.net/hubfs/21140295/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc." }, "text" : "Although an array of scientific advancements is leashing the COVID-19 pandemic to some extent, still a large number of people with compromised immune systems – have been left behind. Because of the recent advancements in cancer therapies, including several chemotherapies and immunotherapies, survival among cancer patients has significantly improved. Unfortunately, these patients remain immunocompromised for a prolonged time as these therapies destroy B-cells that are responsible for antibody-mediated protection, thus lacking sufficient humoral immune responses after vaccination with current SARS-CoV-2 vaccines. The human immune system comprises two lines of defense – B-Cell mediated antibody response and T- Cell-mediated innate response. When patients are immunocompromised, their B-cells are affected, but their T-Cells and innate immune system remain intact. A team of scientists has created a vaccine containing six SARS-CoV-2 antigens from different parts of the virus, unlike just the spike proteins in current vaccines, making it capable of inducing more robust and broader T-cell immunity than the current vaccines. Supported with very robust preliminary data from Phase I/II clinical trials showing T-cell immunity in 71% of subjects after 14 days that increased to 93% in 28 days, a great sigh of relief is on the near horizon for this vulnerable and isolated population. Read the full article here.", "url" : "https://blog.acutis.com/post/aacr22-a-covid-19-vaccine-for-people-with-b-cell-deficiency", "wordCount" : "518" } ``` ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Acutis", "url" : "https://blog.acutis.com/author/acutis" }, "dateModified" : "2023-04-06T01:19:04.466Z", "datePublished" : "2022-06-06T04:00:00.000Z", "headline" : "AACR22: A COVID 19 vaccine for people with B-cell deficiency", "image" : [ "https://blog.acutis.com/hubfs/Imported_Blog_Media/6f340a_bc9908689ede4694b2f61cea55e858b6~mv2-2.jpeg" ], "mainEntityOfPage" : { "@id" : "https://blog.acutis.com/post/aacr22-a-covid-19-vaccine-for-people-with-b-cell-deficiency", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://blog.acutis.com/hubfs/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc. | Acutis Biosciences" } } ```