--- title: US National toxicology program to add IVIVE predictive software description: The US National Toxicology Program (NTP) has developed a crucial tool for clinicians and toxicologists alike called Integrated Chemical Environment (ICE). image: https://blog.acutis.com/hubfs/Imported_Blog_Media/6f340a_d688c11a48a74396aeb6e5e227adf7da~mv2-1.jpg --- [Skip to content](https://blog.acutis.com/post/us-national-toxicology-program-poised-to-add-ivive-predictive-software-to-its-retinue#main-content) Close - About - [What is Acutis?](https://acutis-21140295.hs-sites.com/what-is-acutis) - [Our Team](https://acutis-21140295.hs-sites.com/we-are-acutis) - [Guiding Principles](https://acutis-21140295.hs-sites.com/guiding-principles) - [Compliance](https://acutis-21140295.hs-sites.com/en/compliance) - [Accreditations](https://acutis-21140295.hs-sites.com/accreditations) - [Careers](https://acutis-21140295.hs-sites.com/careers) - [Continuing Education](https://acutis-21140295.hs-sites.com/webinars-symposium) - 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[Insights](https://blog.acutis.com) - [Contact](https://acutis-21140295.hs-sites.com/contact) PHONE HOTLINE: [844-522-8847](tel:+1844-522-8847)E-MAIL: [service@acutis.com](mailto:service@acutis.com) [i-Acutis](https://acutis.careevolve.com/doctors/framepage.asp) ![toxicology lab, pcr lab testing](https://blog.acutis.com/hs-fs/hubfs/Imported_Blog_Media/6f340a_d688c11a48a74396aeb6e5e227adf7da~mv2-1.jpg?width=300&name=6f340a_d688c11a48a74396aeb6e5e227adf7da~mv2-1.jpg) [Acutis](https://blog.acutis.com/author/acutis)Apr 4, 2018 12:00:00 AM1 min read # US National toxicology program to add IVIVE predictive software [Next](https://blog.acutis.com/post/where-a-patient-lives-might-be-influencing-clinician-s-opioid-prescribing-decision-making) ![](https://blog.acutis.com/hubfs/Imported_Blog_Media/6f340a_d688c11a48a74396aeb6e5e227adf7da~mv2.jpg) The US National Toxicology Program (NTP) has recently developed a crucial tool for clinicians and toxicologists alike called Integrated Chemical Environment (ICE). ICE is a central access point for toxicology references and for model predictions to a given substance or hazard. This tool allows robust scientific exploration of the interactions of various substances and can be used for exploratory purposes as well as predictive or confirming needs. Notably, ICE looks to implement a clinical tool called IVIVE. In-vivo-to-in-vitro extrapolation (IVIVE) is a predictive computational tool that enables analyses of substances and interactions from the womb to after birth. This tool can be used for a variety of critical functions past the obvious ones for neonatologists and obstetricians. Linking in vitro activity to in vivo exposures and outcomes can help toxicologists and physicians understand the pathways that drugs take and improve patient outcomes for those of all ages. The US NTP hopes to include tutorials and tools to enable people of all skill levels and backgrounds to use ICE. The tutorials should include simple answers to frequently-asked questions, guides on how to use various models, and other easily-digestible learning tools. These resources are currently under development. The US NTP predicts a 2018 launch date. At Acutis Diagnostics, we make it a point to stay abreast of toxicology and clinical news so we can assist our patients and providers in the best ways possible. ![avatar](https://blog.acutis.com/hs-fs/hubfs/Sales%20materials%202023/Brand/logo-acutis%20HD-2022-1.png?width=290&name=logo-acutis%20HD-2022-1.png) #### [Acutis](https://blog.acutis.com/author/acutis) Our team of scientific experts is here to help you understand the trends in infectious disease, clinical toxicology, and Biosciences that are happening in the world. [mailto:service@acutis.com](mailto:service@acutis.com) ## RELATED ARTICLES [![Acutis-white](https://info.acutis.com/hs-fs/hubfs/Acutis-white.png?width=100&name=Acutis-white.png)](https://www.acutis.com/) **Insights. Answers. 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Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.© 2026 Acutis Diagnostics ```json { "@context" : "https://schema.org", "@type" : "Organization", "address" : { "@type" : "PostalAddress", "addressCountry" : "", "addressLocality" : "Hicksville", "addressRegion" : "NY", "postalCode" : "11801", "streetAddress" : "400 Karin Lane" }, "email" : "service@acutis.com", "knowsLanguage" : "en", "logo" : { "@type" : "ImageObject", "url" : "https://f.hubspotusercontent40.net/hubfs/21140295/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc.", "telephone" : "844-522-8847", "url" : "https://blog.acutis.com/post/us-national-toxicology-program-poised-to-add-ivive-predictive-software-to-its-retinue" } ``` ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "abstract" : "The US National Toxicology Program (NTP) has developed a crucial tool for clinicians and toxicologists alike called Integrated Chemical Environment (ICE).", "author" : { "@type" : "Person", "name" : "Acutis" }, "dateModified" : "April 8, 2023 1 AM", "datePublished" : "April 4, 2018 4 AM", "headline" : "US National toxicology program to add IVIVE predictive software", "image" : "https://info.acutis.com/hubfs/Imported_Blog_Media/6f340a_d688c11a48a74396aeb6e5e227adf7da~mv2-1.jpg", "inLanguage" : "en", "keywords" : "[NEWS]", "mainEntityOfPage" : { "@type" : "WebPage" }, "name" : "US National toxicology program to add IVIVE predictive software", "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://f.hubspotusercontent40.net/hubfs/21140295/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc." }, "text" : "The US National Toxicology Program (NTP) has recently developed a crucial tool for clinicians and toxicologists alike called Integrated Chemical Environment (ICE). ICE is a central access point for toxicology references and for model predictions to a given substance or hazard. This tool allows robust scientific exploration of the interactions of various substances and can be used for exploratory purposes as well as predictive or confirming needs. Notably, ICE looks to implement a clinical tool called IVIVE. In-vivo-to-in-vitro extrapolation (IVIVE) is a predictive computational tool that enables analyses of substances and interactions from the womb to after birth. This tool can be used for a variety of critical functions past the obvious ones for neonatologists and obstetricians. Linking in vitro activity to in vivo exposures and outcomes can help toxicologists and physicians understand the pathways that drugs take and improve patient outcomes for those of all ages. The US NTP hopes to include tutorials and tools to enable people of all skill levels and backgrounds to use ICE. The tutorials should include simple answers to frequently-asked questions, guides on how to use various models, and other easily-digestible learning tools. These resources are currently under development. The US NTP predicts a 2018 launch date. At Acutis Diagnostics, we make it a point to stay abreast of toxicology and clinical news so we can assist our patients and providers in the best ways possible.", "url" : "https://blog.acutis.com/post/us-national-toxicology-program-poised-to-add-ivive-predictive-software-to-its-retinue", "wordCount" : "488" } ``` ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Acutis", "url" : "https://blog.acutis.com/author/acutis" }, "dateModified" : "2023-04-08T01:38:42.740Z", "datePublished" : "2018-04-04T04:00:00.000Z", "headline" : "US National toxicology program to add IVIVE predictive software", "image" : [ "https://blog.acutis.com/hubfs/Imported_Blog_Media/6f340a_d688c11a48a74396aeb6e5e227adf7da~mv2-1.jpg" ], "mainEntityOfPage" : { "@id" : "https://blog.acutis.com/post/us-national-toxicology-program-poised-to-add-ivive-predictive-software-to-its-retinue", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://blog.acutis.com/hubfs/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc. | Acutis Biosciences" } } ```