--- title: Exploring Original Antigenic Sin (OAS) to combat the COVID-19 pandemic description: An aggressive tug-of-war continues between SARS-CoV-2 and scientific developments with a myriad of different options that are helping combat the spread. image: https://blog.acutis.com/hubfs/Imported_Blog_Media/6f340a_67d70f62fb4b4d8fb48510225011e395~mv2-1.jpeg --- [Skip to content](https://blog.acutis.com/post/exploring-original-antigenic-sin-oas-to-combat-the-covid-19-pandemic#main-content) Close - About - [What is Acutis?](https://acutis-21140295.hs-sites.com/what-is-acutis) - [Our Team](https://acutis-21140295.hs-sites.com/we-are-acutis) - [Guiding Principles](https://acutis-21140295.hs-sites.com/guiding-principles) - [Compliance](https://acutis-21140295.hs-sites.com/en/compliance) - [Accreditations](https://acutis-21140295.hs-sites.com/accreditations) - [Careers](https://acutis-21140295.hs-sites.com/careers) - [Continuing Education](https://acutis-21140295.hs-sites.com/webinars-symposium) - Providers - [Infectious Diseases](https://acutis-21140295.hs-sites.com/molecular-tests-infectious-disease) - [Respiratory Pathogen Testing](https://acutis-21140295.hs-sites.com/rit-testing-respiratory-pathogen-tests) - [Gastrointestinal Pathogen Testing](https://acutis-21140295.hs-sites.com/git-testing-gastrointestinal-pathogens-testing) - [Urinary Tract Infection Testing](https://acutis-21140295.hs-sites.com/urinary-tract-infection-testing) - [Sexually Transmitted Infections](https://acutis-21140295.hs-sites.com/sti-testing) - [Pharyngeal Testing](https://acutis-21140295.hs-sites.com/pit-testing-strep-a) - [Clinical Toxicology](https://acutis-21140295.hs-sites.com/clinical-toxicology) - [Medication Monitoring](https://acutis-21140295.hs-sites.com/medication-monitoring-tests) - [Substance Use & Addiction](https://acutis-21140295.hs-sites.com/substance-use-and-addiction) - Patients - [Make a Payment](https://acutis-21140295.hs-sites.com/make-a-payment-as-patient) - [Financial Assistance](https://acutis-21140295.hs-sites.com/patient-financial-assistance) - [FAQs](https://info.acutis.com/patient-faqs) - [Insights](https://blog.acutis.com) - [Contact](https://acutis-21140295.hs-sites.com/contact) CONTACT PHONE HOTLINE: [844-522-8847](tel:+1844-522-8847)E-MAIL: [service@acutis.com](mailto:service@acutis.com) [i-Acutis](https://acutis.careevolve.com/doctors/framepage.asp) [![logo](https://blog.acutis.com/hubfs/logo-Acutis%20HD-2.webp "logo")](https://www.acutis.com/) - About - [What is Acutis?](https://acutis-21140295.hs-sites.com/what-is-acutis) - [Our Team](https://acutis-21140295.hs-sites.com/we-are-acutis) - [Guiding Principles](https://acutis-21140295.hs-sites.com/guiding-principles) - [Compliance](https://acutis-21140295.hs-sites.com/en/compliance) - [Accreditations](https://acutis-21140295.hs-sites.com/accreditations) - [Careers](https://acutis-21140295.hs-sites.com/careers) - [Continuing Education](https://acutis-21140295.hs-sites.com/webinars-symposium) - Providers - [Infectious Diseases](https://acutis-21140295.hs-sites.com/molecular-tests-infectious-disease) - [Respiratory Pathogen Testing](https://acutis-21140295.hs-sites.com/rit-testing-respiratory-pathogen-tests) - [Gastrointestinal Pathogen Testing](https://acutis-21140295.hs-sites.com/git-testing-gastrointestinal-pathogens-testing) - [Urinary Tract Infection Testing](https://acutis-21140295.hs-sites.com/urinary-tract-infection-testing) - [Sexually Transmitted Infections](https://acutis-21140295.hs-sites.com/sti-testing) - [Pharyngeal Testing](https://acutis-21140295.hs-sites.com/pit-testing-strep-a) - [Clinical Toxicology](https://acutis-21140295.hs-sites.com/clinical-toxicology) - [Medication Monitoring](https://acutis-21140295.hs-sites.com/medication-monitoring-tests) - [Substance Use & Addiction](https://acutis-21140295.hs-sites.com/substance-use-and-addiction) - Patients - [Make a Payment](https://acutis-21140295.hs-sites.com/make-a-payment-as-patient) - [Financial Assistance](https://acutis-21140295.hs-sites.com/patient-financial-assistance) - [FAQs](https://info.acutis.com/patient-faqs) - [Insights](https://blog.acutis.com) - [Contact](https://acutis-21140295.hs-sites.com/contact) PHONE HOTLINE: [844-522-8847](tel:+1844-522-8847)E-MAIL: [service@acutis.com](mailto:service@acutis.com) [i-Acutis](https://acutis.careevolve.com/doctors/framepage.asp) ![acutis diagnostics covid pcr testing lab ny, infectious disease lab nj ](https://blog.acutis.com/hs-fs/hubfs/Imported_Blog_Media/6f340a_67d70f62fb4b4d8fb48510225011e395~mv2-1.jpeg?width=300&name=6f340a_67d70f62fb4b4d8fb48510225011e395~mv2-1.jpeg) [Acutis](https://blog.acutis.com/author/acutis)Dec 28, 2021 12:00:00 AM1 min read # Exploring Original Antigenic Sin (OAS) to combat the COVID-19 pandemic [Previous](https://blog.acutis.com/post/study-demonstrates-that-not-all-develop-pcr-or-antibody-positivity-to-sars-cov-2) [Next](https://blog.acutis.com/post/about-new-york-city-s-supervised-drug-injection-sites) ![](https://blog.acutis.com/hubfs/Imported_Blog_Media/6f340a_67d70f62fb4b4d8fb48510225011e395~mv2.jpeg) An aggressive tug-of-war continues between SARS-CoV-2 and scientific developments with a myriad of different options beginning from prevention, diagnostics, vaccination, antibody therapy, and recently some promising [oral therapies](https://www.acutis.com/post/the-first-fda-approved-oral-antiviral-covid-treatment). However, the balance still seems to be tilted towards the virus, and scientists are searching for any possible information to help combat the pandemic. One avenue involves understanding the phenomenon known as the [Original Antigenic Sin](https://pubmed.ncbi.nlm.nih.gov/28479213/) (OAS). As evidenced in seasonal flu, OAS is when some people are better at fighting off seasonal flu when the strain of the flu virus is similar to the first one they encountered in their childhood. Although there is increasing evidence of a similar phenomenon in SARS-CoV-2, it remains unclear to what extent it affects people with COVID-19 and whether it provides enhanced protection or hampers the immune response. While some studies showed the OAS-induced recall of antibody responses to be beneficial, other studies showed OAS-induced antibodies to be less protective against SARS-CoV-2 and even negatively affecting people. This interplay between seasonal coronavirus infection and the disease outcome upon SARS-CoV-2 infection is more complicated than originally thought and needs further analyses before drawing any conclusions. **The full article can be found** [**here**](https://www.nature.com/articles/d41586-021-03087-0)**.**   [CONTACT US](https://www.acutis.com/contact) ![avatar](https://blog.acutis.com/hs-fs/hubfs/Sales%20materials%202023/Brand/logo-acutis%20HD-2022-1.png?width=290&name=logo-acutis%20HD-2022-1.png) #### [Acutis](https://blog.acutis.com/author/acutis) Our team of scientific experts is here to help you understand the trends in infectious disease, clinical toxicology, and Biosciences that are happening in the world. [mailto:service@acutis.com](mailto:service@acutis.com) ## RELATED ARTICLES [![Acutis-white](https://info.acutis.com/hs-fs/hubfs/Acutis-white.png?width=100&name=Acutis-white.png)](https://www.acutis.com/) **Insights. Answers. Outcomes. ** **Diagnostic Excellence. **   400 Karin Lane | Hicksville, NY 11801 68 Culver Road, Monmouth Junction, NJ 08852 - About - [What is Acutis?](https://acutis-21140295.hs-sites.com/what-is-acutis) - [Accreditations](https://acutis-21140295.hs-sites.com/accreditations) - [Payer Relations](https://acutis-21140295.hs-sites.com/payer-relations-information) - [Careers](https://acutis-21140295.hs-sites.com/careers) - [Insights](https://blog.acutis.com) - [Contact](https://acutis-21140295.hs-sites.com/contact) - [HIPAA Privacy](https://acutis-21140295.hs-sites.com/en/hippa-privacy) - [Privacy Practices](https://blog.acutis.com/hubfs/2022%20Notice%20of%20Privacy%20Practices.pdf?hsLang=en) - [Privacy Policy](https://info.acutis.com/privacy-policy) - [SMS Terms and Conditions](https://acutis-21140295.hs-sites.com/sms-terms-conditions) - Providers - [Make a Payment](https://acutis-21140295.hs-sites.com/physician-practice-payment) - [Test Menus](https://acutis-21140295.hs-sites.com/test-menus) - [Arrange Sample Pick-up](https://acutis-21140295.hs-sites.com/physician-practice-sample-pick-up) - [Order POC Cups](https://acutisdiagnostics.myshopify.com/products/bluerapids-concise-12-panel-cup) - [Order Supplies](https://acutis-21140295.hs-sites.com/physician-practice-order-supplies) - Infectious Diseases - Clinical Toxicology - [Annual Physicians Notice](https://www.acutis.com/hubfs/2022%20Annual%20Physician%20Notice.pdf) - [Provider FAQs](https://info.acutis.com/general-faqs) - Patients - [Patient Payment Link](https://acutis-21140295.hs-sites.com/make-a-payment-as-patient) - [Patient FAQs](https://info.acutis.com/patient-faqs) - [Patient Financial Assistance](https://acutis-21140295.hs-sites.com/patient-financial-assistance) - [Biopharma](https://biosciences.acutis.com) - [Oncology](https://biosciences.acutis.com/oncology) - [Infectious Disease](https://biosciences.acutis.com/infectious-disease) All rights reserved | THIS WEBSITE DOES NOT PROVIDE MEDICAL ADVICE. The information on this website is not intended to substitute for or be relied upon as medical advice, diagnosis, or treatment. This website is for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.© 2026 Acutis Diagnostics ```json { "@context" : "https://schema.org", "@type" : "Organization", "address" : { "@type" : "PostalAddress", "addressCountry" : "", "addressLocality" : "Hicksville", "addressRegion" : "NY", "postalCode" : "11801", "streetAddress" : "400 Karin Lane" }, "email" : "service@acutis.com", "knowsLanguage" : "en", "logo" : { "@type" : "ImageObject", "url" : "https://f.hubspotusercontent40.net/hubfs/21140295/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc.", "telephone" : "844-522-8847", "url" : "https://blog.acutis.com/post/exploring-original-antigenic-sin-oas-to-combat-the-covid-19-pandemic" } ``` ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "abstract" : "An aggressive tug-of-war continues between SARS-CoV-2 and scientific developments with a myriad of different options that are helping combat the spread.", "author" : { "@type" : "Person", "name" : "Acutis" }, "dateModified" : "April 7, 2023 10 PM", "datePublished" : "December 28, 2021 5 AM", "headline" : "Exploring Original Antigenic Sin (OAS) to combat the COVID-19 pandemic", "image" : "https://info.acutis.com/hubfs/Imported_Blog_Media/6f340a_67d70f62fb4b4d8fb48510225011e395~mv2-1.jpeg", "inLanguage" : "en", "keywords" : "[NEWS]", "mainEntityOfPage" : { "@type" : "WebPage" }, "name" : "Exploring Original Antigenic Sin (OAS) to combat the COVID-19 pandemic", "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://f.hubspotusercontent40.net/hubfs/21140295/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc." }, "text" : "An aggressive tug-of-war continues between SARS-CoV-2 and scientific developments with a myriad of different options beginning from prevention, diagnostics, vaccination, antibody therapy, and recently some promising oral therapies. However, the balance still seems to be tilted towards the virus, and scientists are searching for any possible information to help combat the pandemic. One avenue involves understanding the phenomenon known as the Original Antigenic Sin (OAS). As evidenced in seasonal flu, OAS is when some people are better at fighting off seasonal flu when the strain of the flu virus is similar to the first one they encountered in their childhood. Although there is increasing evidence of a similar phenomenon in SARS-CoV-2, it remains unclear to what extent it affects people with COVID-19 and whether it provides enhanced protection or hampers the immune response. While some studies showed the OAS-induced recall of antibody responses to be beneficial, other studies showed OAS-induced antibodies to be less protective against SARS-CoV-2 and even negatively affecting people. This interplay between seasonal coronavirus infection and the disease outcome upon SARS-CoV-2 infection is more complicated than originally thought and needs further analyses before drawing any conclusions. The full article can be found here. CONTACT US", "url" : "https://blog.acutis.com/post/exploring-original-antigenic-sin-oas-to-combat-the-covid-19-pandemic", "wordCount" : "658" } ``` ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Acutis", "url" : "https://blog.acutis.com/author/acutis" }, "dateModified" : "2023-04-07T22:55:30.595Z", "datePublished" : "2021-12-28T05:00:00.000Z", "headline" : "Exploring Original Antigenic Sin (OAS) to combat the COVID-19 pandemic", "image" : [ "https://blog.acutis.com/hubfs/Imported_Blog_Media/6f340a_67d70f62fb4b4d8fb48510225011e395~mv2-1.jpeg" ], "mainEntityOfPage" : { "@id" : "https://blog.acutis.com/post/exploring-original-antigenic-sin-oas-to-combat-the-covid-19-pandemic", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://blog.acutis.com/hubfs/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc. | Acutis Biosciences" } } ```