--- title: Study demonstrates that not all develop PCR or antibody positivity to SARS-CoV-2 description: "Scientists continue to gain a better understanding of the many facets of COVID-19, such as how to: Enhance the vaccine efficacy and prevent transmission." image: https://blog.acutis.com/hubfs/Imported_Blog_Media/6f340a_2b03cdf5f1af4d3a8a6c1532ae7dc0e6~mv2.jpeg --- [Skip to content](https://blog.acutis.com/post/study-demonstrates-that-not-all-develop-pcr-or-antibody-positivity-to-sars-cov-2#main-content) Close - About - [What is Acutis?](https://acutis-21140295.hs-sites.com/what-is-acutis) - [Our Team](https://acutis-21140295.hs-sites.com/we-are-acutis) - [Guiding Principles](https://acutis-21140295.hs-sites.com/guiding-principles) - [Compliance](https://acutis-21140295.hs-sites.com/en/compliance) - [Accreditations](https://acutis-21140295.hs-sites.com/accreditations) - [Careers](https://acutis-21140295.hs-sites.com/careers) - [Continuing Education](https://acutis-21140295.hs-sites.com/webinars-symposium) - 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[Insights](https://blog.acutis.com) - [Contact](https://acutis-21140295.hs-sites.com/contact) PHONE HOTLINE: [844-522-8847](tel:+1844-522-8847)E-MAIL: [service@acutis.com](mailto:service@acutis.com) [i-Acutis](https://acutis.careevolve.com/doctors/framepage.asp) ![pcr testing lab, lab testing ny nj ](https://blog.acutis.com/hs-fs/hubfs/Imported_Blog_Media/6f340a_2b03cdf5f1af4d3a8a6c1532ae7dc0e6~mv2.jpeg?width=300&name=6f340a_2b03cdf5f1af4d3a8a6c1532ae7dc0e6~mv2.jpeg) [Acutis](https://blog.acutis.com/author/acutis)Dec 10, 2021 12:00:00 AM1 min read # Study demonstrates that not all develop PCR or antibody positivity to SARS-CoV-2 [Previous](https://blog.acutis.com/post/scientists-search-for-people-with-genetic-resistance-to-sars-cov-2-infection) [Next](https://blog.acutis.com/post/exploring-original-antigenic-sin-oas-to-combat-the-covid-19-pandemic) ![](https://blog.acutis.com/hubfs/Imported_Blog_Media/6f340a_2b03cdf5f1af4d3a8a6c1532ae7dc0e6~mv2-1.jpeg) Scientists continue to gain a better understanding of the many facets of COVID-19, such as how to: **· Enhance the vaccine efficacy** **· Prevent COVID-19 transmission** **· Better manage infected individuals** **· Diagnose infections promptly with the highest degree of sensitivity and specificity** Of all of these obstacles, one of the first challenges for scientists to overcome was devising effective diagnostics for SARS-CoV-2, which they achieved in record time. However, as newer information emerges daily, it seems like we still do not have a complete picture of all aspects of COVID-19. In an eloquent article from [Nature](https://www.nature.com/), a group of scientists from the United Kingdom utilized an intensively monitored cohort of healthcare workers with potential exposure during the first UK pandemic wave. Comparing those with or without PCR and/or antibody evidence of SARS-CoV-2 infection, this study demonstrated that not all with potential exposure to SARS-CoV-2 developed PCR or antibody positivity, potentially due to clearing the sub-clinical infection before seroconversion – the phenomenon they coined as ‘Abortive, Seronegative SARS-CoV-2 Infection.’ In such instances where PCR and the most sensitive antibody tests remained repeatedly negative, T-cell assays might be able to detect those subclinical infections since these individuals would exhibit pre-existing memory T-cells with cross-reactive potential. [**Learn more here.**](https://www.nature.com/articles/s41586-021-04186-8) ![avatar](https://blog.acutis.com/hs-fs/hubfs/Sales%20materials%202023/Brand/logo-acutis%20HD-2022-1.png?width=290&name=logo-acutis%20HD-2022-1.png) #### [Acutis](https://blog.acutis.com/author/acutis) Our team of scientific experts is here to help you understand the trends in infectious disease, clinical toxicology, and Biosciences that are happening in the world. [mailto:service@acutis.com](mailto:service@acutis.com) ## RELATED ARTICLES [![Acutis-white](https://info.acutis.com/hs-fs/hubfs/Acutis-white.png?width=100&name=Acutis-white.png)](https://www.acutis.com/) **Insights. Answers. 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Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.© 2026 Acutis Diagnostics ```json { "@context" : "https://schema.org", "@type" : "Organization", "address" : { "@type" : "PostalAddress", "addressCountry" : "", "addressLocality" : "Hicksville", "addressRegion" : "NY", "postalCode" : "11801", "streetAddress" : "400 Karin Lane" }, "email" : "service@acutis.com", "knowsLanguage" : "en", "logo" : { "@type" : "ImageObject", "url" : "https://f.hubspotusercontent40.net/hubfs/21140295/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc.", "telephone" : "844-522-8847", "url" : "https://blog.acutis.com/post/study-demonstrates-that-not-all-develop-pcr-or-antibody-positivity-to-sars-cov-2" } ``` ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "abstract" : "Scientists continue to gain a better understanding of the many facets of COVID-19, such as how to: Enhance the vaccine efficacy and prevent transmission.", "author" : { "@type" : "Person", "name" : "Acutis" }, "dateModified" : "April 7, 2023 9 PM", "datePublished" : "December 10, 2021 5 AM", "headline" : "Study demonstrates that not all develop PCR or antibody positivity to SARS-CoV-2", "image" : "https://info.acutis.com/hubfs/Imported_Blog_Media/6f340a_2b03cdf5f1af4d3a8a6c1532ae7dc0e6~mv2.jpeg", "inLanguage" : "en", "keywords" : "[NEWS]", "mainEntityOfPage" : { "@type" : "WebPage" }, "name" : "Study demonstrates that not all develop PCR or antibody positivity to SARS-CoV-2", "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://f.hubspotusercontent40.net/hubfs/21140295/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc." }, "text" : "Scientists continue to gain a better understanding of the many facets of COVID-19, such as how to: · Enhance the vaccine efficacy · Prevent COVID-19 transmission · Better manage infected individuals · Diagnose infections promptly with the highest degree of sensitivity and specificity Of all of these obstacles, one of the first challenges for scientists to overcome was devising effective diagnostics for SARS-CoV-2, which they achieved in record time. However, as newer information emerges daily, it seems like we still do not have a complete picture of all aspects of COVID-19. In an eloquent article from Nature, a group of scientists from the United Kingdom utilized an intensively monitored cohort of healthcare workers with potential exposure during the first UK pandemic wave. Comparing those with or without PCR and/or antibody evidence of SARS-CoV-2 infection, this study demonstrated that not all with potential exposure to SARS-CoV-2 developed PCR or antibody positivity, potentially due to clearing the sub-clinical infection before seroconversion – the phenomenon they coined as ‘Abortive, Seronegative SARS-CoV-2 Infection.’ In such instances where PCR and the most sensitive antibody tests remained repeatedly negative, T-cell assays might be able to detect those subclinical infections since these individuals would exhibit pre-existing memory T-cells with cross-reactive potential. Learn more here.", "url" : "https://blog.acutis.com/post/study-demonstrates-that-not-all-develop-pcr-or-antibody-positivity-to-sars-cov-2", "wordCount" : "713" } ``` ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Acutis", "url" : "https://blog.acutis.com/author/acutis" }, "dateModified" : "2023-04-07T21:16:13.001Z", "datePublished" : "2021-12-10T05:00:00.000Z", "headline" : "Study demonstrates that not all develop PCR or antibody positivity to SARS-CoV-2", "image" : [ "https://blog.acutis.com/hubfs/Imported_Blog_Media/6f340a_2b03cdf5f1af4d3a8a6c1532ae7dc0e6~mv2.jpeg" ], "mainEntityOfPage" : { "@id" : "https://blog.acutis.com/post/study-demonstrates-that-not-all-develop-pcr-or-antibody-positivity-to-sars-cov-2", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://blog.acutis.com/hubfs/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc. | Acutis Biosciences" } } ```