--- title: "- Science Direct" description: UTIs are one of the most common bacterial infections infecting any part of the urinary system from the urethra, bladder, and ureter, to the kidney. image: https://blog.acutis.com/hubfs/blog-A%20Pseudomonas%20aeruginos-2%20copy.jpg --- [Skip to content](https://blog.acutis.com/a-pseudomonas-aeruginosa-pqs-quorum-sensing-system-inhibitor-with-anti-staphylococcal-activity-sensitizes-polymicrobial-biofilms-to-tobramycin-sciencedirect-1#main-content) Close - About - [What is Acutis?](https://acutis-21140295.hs-sites.com/what-is-acutis) - [Our Team](https://acutis-21140295.hs-sites.com/we-are-acutis) - [Guiding Principles](https://acutis-21140295.hs-sites.com/guiding-principles) - [Compliance](https://acutis-21140295.hs-sites.com/en/compliance) - [Accreditations](https://acutis-21140295.hs-sites.com/accreditations) - [Careers](https://acutis-21140295.hs-sites.com/careers) - [Continuing Education](https://acutis-21140295.hs-sites.com/webinars-symposium) - Providers - [Infectious Diseases](https://acutis-21140295.hs-sites.com/molecular-tests-infectious-disease) - [Respiratory Pathogen Testing](https://acutis-21140295.hs-sites.com/rit-testing-respiratory-pathogen-tests) - [Gastrointestinal Pathogen Testing](https://acutis-21140295.hs-sites.com/git-testing-gastrointestinal-pathogens-testing) - [Urinary Tract Infection Testing](https://acutis-21140295.hs-sites.com/urinary-tract-infection-testing) - [Sexually Transmitted Infections](https://acutis-21140295.hs-sites.com/sti-testing) - [Pharyngeal Testing](https://acutis-21140295.hs-sites.com/pit-testing-strep-a) - [Clinical Toxicology](https://acutis-21140295.hs-sites.com/clinical-toxicology) - [Medication Monitoring](https://acutis-21140295.hs-sites.com/medication-monitoring-tests) - [Substance Use & Addiction](https://acutis-21140295.hs-sites.com/substance-use-and-addiction) - Patients - [Make a Payment](https://acutis-21140295.hs-sites.com/make-a-payment-as-patient) - [Financial Assistance](https://acutis-21140295.hs-sites.com/patient-financial-assistance) - [FAQs](https://info.acutis.com/patient-faqs) - [Insights](https://blog.acutis.com) - [Contact](https://acutis-21140295.hs-sites.com/contact) CONTACT PHONE HOTLINE: [844-522-8847](tel:+1844-522-8847)E-MAIL: [service@acutis.com](mailto:service@acutis.com) [i-Acutis](https://acutis.careevolve.com/doctors/framepage.asp) [![logo](https://blog.acutis.com/hubfs/logo-Acutis%20HD-2.webp "logo")](https://www.acutis.com/) - About - [What is Acutis?](https://acutis-21140295.hs-sites.com/what-is-acutis) - [Our Team](https://acutis-21140295.hs-sites.com/we-are-acutis) - [Guiding Principles](https://acutis-21140295.hs-sites.com/guiding-principles) - [Compliance](https://acutis-21140295.hs-sites.com/en/compliance) - [Accreditations](https://acutis-21140295.hs-sites.com/accreditations) - [Careers](https://acutis-21140295.hs-sites.com/careers) - [Continuing Education](https://acutis-21140295.hs-sites.com/webinars-symposium) - Providers - [Infectious Diseases](https://acutis-21140295.hs-sites.com/molecular-tests-infectious-disease) - [Respiratory Pathogen Testing](https://acutis-21140295.hs-sites.com/rit-testing-respiratory-pathogen-tests) - [Gastrointestinal Pathogen Testing](https://acutis-21140295.hs-sites.com/git-testing-gastrointestinal-pathogens-testing) - [Urinary Tract Infection Testing](https://acutis-21140295.hs-sites.com/urinary-tract-infection-testing) - [Sexually Transmitted Infections](https://acutis-21140295.hs-sites.com/sti-testing) - [Pharyngeal Testing](https://acutis-21140295.hs-sites.com/pit-testing-strep-a) - [Clinical Toxicology](https://acutis-21140295.hs-sites.com/clinical-toxicology) - [Medication Monitoring](https://acutis-21140295.hs-sites.com/medication-monitoring-tests) - [Substance Use & Addiction](https://acutis-21140295.hs-sites.com/substance-use-and-addiction) - Patients - [Make a Payment](https://acutis-21140295.hs-sites.com/make-a-payment-as-patient) - [Financial Assistance](https://acutis-21140295.hs-sites.com/patient-financial-assistance) - [FAQs](https://info.acutis.com/patient-faqs) - [Insights](https://blog.acutis.com) - [Contact](https://acutis-21140295.hs-sites.com/contact) PHONE HOTLINE: [844-522-8847](tel:+1844-522-8847)E-MAIL: [service@acutis.com](mailto:service@acutis.com) [i-Acutis](https://acutis.careevolve.com/doctors/framepage.asp) ![blog-A Pseudomonas aeruginos-2 copy-1](https://blog.acutis.com/hs-fs/hubfs/blog-A%20Pseudomonas%20aeruginos-2%20copy-1.jpg?width=300&name=blog-A%20Pseudomonas%20aeruginos-2%20copy-1.jpg) [Batu Sharma, PhD](https://blog.acutis.com/author/batu-sharma-phd)May 19, 2023 2:06:32 PM1 min read # - Science Direct [Previous](https://blog.acutis.com/fda-approves-first-respiratory-syncytial-virus-rsv-vaccine-fda) [Next](https://blog.acutis.com/mail-back-envelopes-for-opioid-analgesics-dispensed-in-outpatient-settings-fda) Urinary tract infection (UTI) is one of the most common bacterial infections infecting any part of the urinary system from the urethra, bladder, and ureter, to the kidney. It affects more than 150 million people worldwide both in the community and hospital setting. In most of the complicated and chronic UTIs, biofilm - a community of bacterial cells sticking together, and attaching to the bladder wall, is involved. Unfortunately, many antimicrobial-resistant UTI pathogens like Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, etc. form biofilms.   In order to manage difficult-to-eradicate biofilm-associated chronic infections like UTIs, innovative approaches to tackling biofilm formation are urgently needed. In an eloquent study, Scientists from the UK explored the library of quinazolinones (QZNs) antibiotics and discovered that a subset of PqsR QZN antagonists showed activity against biofilm as well as planktonic cells of P. aeruginosa and effectively damaged S. aureus biofilms, paving a path forward for exploiting the QZN scaffold for anti-infective/anti-biofilm drug development.   While such discoveries would ultimately be helpful, as of now, diagnosing UTIs right away using prominent diagnostic tests like [Acutis Reveal™ UTI](https://www.acutis.com/urinary-tract-infection-testing), a multiplex PCR-based test with 96-100% sensitivity and 100% specificity, is the way forward to ensure the proper management of UTIs. **Read the full article >> [here](https://www.sciencedirect.com/science/article/pii/S2451945622000885#bib32)** ![avatar](https://blog.acutis.com/hs-fs/hubfs/Dr.%20Batu%20Author%20Icon.png?width=290&name=Dr.%20Batu%20Author%20Icon.png) #### [Batu Sharma, PhD](https://blog.acutis.com/author/batu-sharma-phd) Experienced Medical/Scientific Writer working in Vaccines/Antimicrobial Drug/Device/Diagnostics ## RELATED ARTICLES [![Acutis-white](https://info.acutis.com/hs-fs/hubfs/Acutis-white.png?width=100&name=Acutis-white.png)](https://www.acutis.com/) **Insights. Answers. Outcomes. ** **Diagnostic Excellence. **   400 Karin Lane | Hicksville, NY 11801 68 Culver Road, Monmouth Junction, NJ 08852 - About - [What is Acutis?](https://acutis-21140295.hs-sites.com/what-is-acutis) - [Accreditations](https://acutis-21140295.hs-sites.com/accreditations) - [Payer Relations](https://acutis-21140295.hs-sites.com/payer-relations-information) - [Careers](https://acutis-21140295.hs-sites.com/careers) - [Insights](https://blog.acutis.com) - [Contact](https://acutis-21140295.hs-sites.com/contact) - [HIPAA Privacy](https://acutis-21140295.hs-sites.com/en/hippa-privacy) - [Privacy Practices](https://blog.acutis.com/hubfs/2022%20Notice%20of%20Privacy%20Practices.pdf?hsLang=en) - [Privacy Policy](https://info.acutis.com/privacy-policy) - [SMS Terms and Conditions](https://acutis-21140295.hs-sites.com/sms-terms-conditions) - Providers - [Make a Payment](https://acutis-21140295.hs-sites.com/physician-practice-payment) - [Test Menus](https://acutis-21140295.hs-sites.com/test-menus) - [Arrange Sample Pick-up](https://acutis-21140295.hs-sites.com/physician-practice-sample-pick-up) - [Order POC Cups](https://acutisdiagnostics.myshopify.com/products/bluerapids-concise-12-panel-cup) - [Order Supplies](https://acutis-21140295.hs-sites.com/physician-practice-order-supplies) - Infectious Diseases - Clinical Toxicology - [Annual Physicians Notice](https://www.acutis.com/hubfs/2022%20Annual%20Physician%20Notice.pdf) - [Provider FAQs](https://info.acutis.com/general-faqs) - Patients - [Patient Payment Link](https://acutis-21140295.hs-sites.com/make-a-payment-as-patient) - [Patient FAQs](https://info.acutis.com/patient-faqs) - [Patient Financial Assistance](https://acutis-21140295.hs-sites.com/patient-financial-assistance) - [Biopharma](https://biosciences.acutis.com) - [Oncology](https://biosciences.acutis.com/oncology) - [Infectious Disease](https://biosciences.acutis.com/infectious-disease) All rights reserved | THIS WEBSITE DOES NOT PROVIDE MEDICAL ADVICE. The information on this website is not intended to substitute for or be relied upon as medical advice, diagnosis, or treatment. This website is for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.© 2026 Acutis Diagnostics ```json { "@context" : "https://schema.org", "@type" : "Organization", "address" : { "@type" : "PostalAddress", "addressCountry" : "", "addressLocality" : "Hicksville", "addressRegion" : "NY", "postalCode" : "11801", "streetAddress" : "400 Karin Lane" }, "email" : "service@acutis.com", "knowsLanguage" : "en", "logo" : { "@type" : "ImageObject", "url" : "https://f.hubspotusercontent40.net/hubfs/21140295/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc.", "telephone" : "844-522-8847", "url" : "https://blog.acutis.com/a-pseudomonas-aeruginosa-pqs-quorum-sensing-system-inhibitor-with-anti-staphylococcal-activity-sensitizes-polymicrobial-biofilms-to-tobramycin-sciencedirect-1" } ``` ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "abstract" : "UTIs are one of the most common bacterial infections infecting any part of the urinary system from the urethra, bladder, and ureter, to the kidney.", "author" : { "@type" : "Person", "name" : "Batu Sharma, PhD" }, "dateModified" : "May 19, 2023 6 PM", "datePublished" : "May 19, 2023 6 PM", "headline" : "- Science Direct", "image" : "https://info.acutis.com/hubfs/blog-A%20Pseudomonas%20aeruginos-2%20copy.jpg", "inLanguage" : "en", "keywords" : "[EDUCATION]", "mainEntityOfPage" : { "@type" : "WebPage" }, "name" : "- Science Direct", "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://f.hubspotusercontent40.net/hubfs/21140295/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc." }, "text" : "Urinary tract infection (UTI) is one of the most common bacterial infections infecting any part of the urinary system from the urethra, bladder, and ureter, to the kidney. It affects more than 150 million people worldwide both in the community and hospital setting. In most of the complicated and chronic UTIs, biofilm - a community of bacterial cells sticking together, and attaching to the bladder wall, is involved. Unfortunately, many antimicrobial-resistant UTI pathogens like Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, etc. form biofilms. In order to manage difficult-to-eradicate biofilm-associated chronic infections like UTIs, innovative approaches to tackling biofilm formation are urgently needed. In an eloquent study, Scientists from the UK explored the library of quinazolinones (QZNs) antibiotics and discovered that a subset of PqsR QZN antagonists showed activity against biofilm as well as planktonic cells of P. aeruginosa and effectively damaged S. aureus biofilms, paving a path forward for exploiting the QZN scaffold for anti-infective/anti-biofilm drug development. While such discoveries would ultimately be helpful, as of now, diagnosing UTIs right away using prominent diagnostic tests like Acutis Reveal™ UTI, a multiplex PCR-based test with 96-100% sensitivity and 100% specificity, is the way forward to ensure the proper management of UTIs. Read the full article >> here", "url" : "https://blog.acutis.com/a-pseudomonas-aeruginosa-pqs-quorum-sensing-system-inhibitor-with-anti-staphylococcal-activity-sensitizes-polymicrobial-biofilms-to-tobramycin-sciencedirect-1", "wordCount" : "294" } ``` ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Batu Sharma, PhD", "url" : "https://blog.acutis.com/author/batu-sharma-phd" }, "dateModified" : "2023-05-19T18:06:32.298Z", "datePublished" : "2023-05-19T18:06:32.000Z", "headline" : "- Science Direct", "image" : [ "https://blog.acutis.com/hubfs/blog-A%20Pseudomonas%20aeruginos-2%20copy.jpg" ], "mainEntityOfPage" : { "@id" : "https://blog.acutis.com/a-pseudomonas-aeruginosa-pqs-quorum-sensing-system-inhibitor-with-anti-staphylococcal-activity-sensitizes-polymicrobial-biofilms-to-tobramycin-sciencedirect-1", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://blog.acutis.com/hubfs/logo-Acutis%20HD-2.webp" }, "name" : "Acutis Diagnostics Inc. | Acutis Biosciences" } } ```